Influenza M2 virus-like particle vaccination enhances protection in combination with avian influenza HA VLPs.

Despite the ability to induce a broad range of cross protection, M2e5x virus-like particles (VLPs) alone provide limited vaccine efficacy and confer low efficacy of protection against highly pathogenic avian influenza virus (HPAIV) infection in chickens.Avian influenza hemagglutinin (HA) has been a major antigenic target that enhances humoral immun

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